NAD section medically authored by Dr. Eric Muradov ND - Naturopathic Doctor

NAD+ IV Therapy & NAD+ Injections in Edmonton

Advanced Nutrient Infusion Therapy at TruMed, Led by Dr. Eric Muradov

TruMed is a leading provider of NAD+ IV therapy and NAD+ injections in Edmonton, with extensive clinical experience under the guidance of Dr. Eric Muradov, a Naturopathic Doctor specializing in advanced intravenous nutrient protocols.

What is NAD+?

Nicotinamide Adenine Dinucleotide (NAD⁺) is a critical coenzyme found in every living cell, where it plays a central role in cellular metabolism, mitochondrial energy production (ATP), DNA repair, and cellular resilience. NAD+ also modulates key longevity genes (SIRT1–SIRT7) and supports neurological and cognitive function.

Why NAD+ IV Therapy?

Due to NAD+’s limited oral bioavailability, IV administration allows for rapid, direct delivery into circulation, bypassing gastrointestinal degradation. In clinical studies and patient experience, IV NAD+ therapy has shown potential in:

• Enhancing energy and reducing fatigue, including in cases of chronic fatigue syndrome and fibromyalgia

• Supporting detoxification and substance withdrawal, particularly from alcohol and opioids

• Improving mood, cognitive clarity, and neurological function

• Promoting healthy aging, DNA repair, and mitochondrial health

• Complementing Hyperbaric Oxygen Therapy, which provides additional oxidative substrate for NAD⁺-dependent mitochondrial respiration

NAD+ Injections and IV Dosing at TruMed

Our Edmonton clinic offers both low and high-dose NAD+ injections and IV infusions, tailored to your clinical goals.

Standard NAD+ IV Protocols:

• Fatigue & Energy Support: 250–500mg IV over ~60 minutes, often combined with oral mitochondrial cofactors such as nicotinamide riboside, NMN, or NADH

• Anti-aging: Weekly 250–750mg NAD+ infusions as part of long-term cellular rejuvenation programs

• Substance Withdrawal Support: 500–1000mg NAD+ IV on Day 1, with tapering doses over 3–5 consecutive days, supported by B1, B3, Vitamin C, magnesium, and hydration

• Neurocognitive Enhancement: Daily 750–1500mg over 6–10 days, based on protocols studied in age-related cognitive decline

NAD+ IVs are often combined with other synergistic therapies such as:

• Myers’ Cocktails

• High-dose Vitamin C

• Glutathione pushes

• IV amino acid blends

We also offer the “Elite IV NAD+” protocol:

• 25g IV Vitamin C

• Myers’ Cocktail

• 1500mg NAD+ IV

• Glutathione & amino acids

Clinical Use in Fatigue, Addiction & Neurology

Our Edmonton-based naturopathic team has used NAD+ IV therapy to address:

Fatigue Syndromes:

NAD+ plays a vital role in oxidative phosphorylation and ATP production. Many patients report a rapid boost in mental and physical energy—sometimes even before the IV is complete.

Addiction & Withdrawal:

Intravenous NAD+ has been studied for its role in reducing cravings and easing withdrawal symptoms in patients addicted to alcohol, opioids, and stimulants. In many cases, this therapy has been shown to reduce relapse rates and stabilize mood over the long term.

Cognitive & Neurological Health:

Age-related NAD+ decline has been linked to impaired neurogenesis, oxidative stress, and mitochondrial dysfunction. In murine studies, NAD+ repletion restored hippocampal NAD+ levels and improved cognitive outcomes. Human studies show promise for age-related memory concerns.

Biochemistry & Mechanisms

NAD+ is synthesized through three metabolic pathways:

1. De novo from tryptophan via the kynurenine pathway

2. Preiss-Handler pathway from nicotinic acid

3. Salvage pathway from nicotinamide, nicotinamide riboside (NR), or NMN

NAD+ functions include:

• ATP generation via glycolysis, TCA cycle, and electron transport chain (as NADH)

• Redox reactions and antioxidant regeneration (e.g., converting oxidized glutathione via NADPH)

• DNA repair via PARP enzymes

• Sirtuin activity for gene regulation and neuroprotection

• Serotonin synthesis and mood regulation

• Autophagy and mitophagy induction for cellular longevity

Research Highlights

• O’Hollaren (1961): Early work demonstrating NAD+ IV therapy significantly reduced alcohol cravings.

• Dr. William Hitt (1990s): Treated over 100 cases of chemical dependency with IV NAD+, vitamins, and amino acids—reporting decreased withdrawal symptoms and relapse rates.

• Susan Broom, PhD (2008 & 2014): Pilot studies on BR+NAD therapy (IV NAD+ with amino acids and vitamins) showed significant reductions in cravings, depression, and anxiety in patients recovering from alcohol and opiate dependence.

• Grant (2019): Tracked NAD+ pharmacokinetics during IV administration—demonstrated rapid cellular uptake during the first two hours of infusion.

• Blum (2022): Showed enhanced addiction recovery outcomes using IV NAD+, glutathione, alpha-lipoic acid, and a full micronutrient support protocol.

Safety and Side Effects

When administered at controlled rates (≤4mg/min), NAD+ IV therapy is well tolerated. Side effects are usually mild and dose-rate dependent:

• Most common: Temporary nausea, especially at faster infusion rates

• Others: Headache, chest pressure, lightheadedness

• Rare: Diarrhea

• Most reported effect: Increased energy and mental clarity

In over six years of NAD+ IV administration at TruMed, no laboratory abnormalities or toxicities have been observed.

NAD+ for Brain Health

Our clinic is deeply focused on the role of NAD+ in neurodegeneration, particularly in older adults. Research indicates:

• A 40% drop in hippocampal NAD+ levels in aged mice

• Restoration of mitochondrial function and neurogenesis with NAD+ therapy

• Protection against oxidative stress and enhancement of DNA repair pathways

NAD+ augmentation may be especially relevant for Edmonton patients experiencing cognitive decline, brain fog, or early neurological symptoms.

Start Your NAD+ IV Therapy in Edmonton

At TruMed, we make NAD+ injections and NAD+ IV therapy accessible, affordable, and evidence-based. Whether you're seeking enhanced energy, support during withdrawal, or long-term cognitive and mitochondrial health, our Naturopathic Doctors are here to guide you with precision and care.

???? Contact us at (780) 757-8378 to schedule your NAD+ consultation in Edmonton.

 NAD+ Injections and IV Therapy in Edmonton

Our Naturopaths often once weekly NAD Injection treatments, typically looking to build cumulative dose of 800-1000mg after which patients need a booster injection every 3-4 weeks.

We also offer subcutaneous NAD injections that patients can take home and administer to themselves in between IV NAD at our office.

Common side effects to NAD infusions includes nausea, rapid heart rate and lightheadedness which is completely rate dependent. In other words, the infusion is slowed, the symptoms tend to resolve.

A 2017 human study showed that intravenous NAD+ is rapidly and completely removed from the plasma (taken up by cells) for the first two hours of NAD IV administration.

Hypothetically, the older a patient is, the larger the effect we see from NAD+ IV Therapy, as levels of NAD+ naturally decline as we age.

Because of mechanistic overlap, NAD+ injection treatments can be enhanced with the inclusion of a Vitamin Cocktail - the B-Vitamins and Magnesium that we put in our IV Drips in particular can help drive the Krebs cycle and enhance effects of NAD IV Therapy. 

The B-Vitamins and NAD+ IV can be administered together in one intravenous treatment (same IV Drip bag).

At Edmonton office has substantial experience with NAD IV therapy - we have given literally thousands of NAD infusion and injections in Edmonton since 2015.

Glutathione injections can be added to the tail end of NAD+ IV Therapy.

IV NAD+ injections for substance abuse can be anywhere from 3 - 10 consecutive days of treatment with doses frequently between 500-1000mg. These NAD infusions can take 5-8 hours.

IV NAD+ treatments for substance abuse enhances energy, calmness, clarity of thought as well as a reduction in cravings.

NAD IV Therapy for Fatigue

Running on empty? NAD+ has become increasingly popular among people looking for more energy, better resilience and support for cellular metabolism. NAD+ is a coenzyme involved in energy production and numerous cellular processes, which makes it particularly interesting when fatigue and reduced stamina are part of the picture. Learn more about our approach to fatigue and how our Edmonton Naturopathic Doctors investigate the underlying factors that may be draining your energy. At TruMed, NAD IV Therapy can be considered alongside nutritional assessment, thyroid testing, iron studies, hormone evaluation and other appropriate investigations. For some patients, NAD+ is combined with B vitamins, magnesium, vitamin C or other IV nutrients to create a more comprehensive IV Therapy Edmonton protocol.

NAD IV Therapy for Women's Health

Women can experience major changes in energy and resilience throughout menstruation, pregnancy, postpartum recovery, perimenopause and menopause. NAD+ has attracted attention in longevity and cellular-energy research and may be considered as part of an individualized wellness strategy. Explore our  women's health approach and how NAD IV Therapy may fit into a broader plan addressing energy, hormones, nutrition and healthy aging. Depending on individual needs, NAD IV Therapy may be combined with vitamin infusions, magnesium, glutathione or other nutrients. Our Edmonton Naturopathic Doctors look at the whole picture rather than assuming every bout of fatigue is simply “hormonal.”

NAD IV Therapy for Hormones

Hormones and cellular energy have an interesting relationship. Changes in estrogen, progesterone, testosterone and thyroid hormones can influence energy, sleep, mood, body composition and how well you recover from stress and exercise. Learn more about our approach to hormone health and how NAD IV Therapy can complement a broader hormonal and longevity strategy. NAD+ is involved in cellular energy metabolism and is therefore particularly interesting in the context of healthy aging. At TruMed, NAD IV Therapy may be combined with appropriate vitamin IVs, glutathione and other supportive treatments based on your individual goals and clinical assessment.

NAD IV Therapy for Digestive Concerns

When your digestive system is unhappy, everything else can feel a little harder—including maintaining energy and keeping up with everyday life. While NAD+ isn't a treatment for digestive disease itself, NAD IV Therapy may provide a way to support cellular energy and nutritional status without relying on gastrointestinal absorption. Learn more about our approach to digestive concerns and how we look beyond the gut symptoms to identify nutritional and metabolic factors that may be contributing to how you feel. Depending on the patient, an Edmonton IV Therapy protocol may combine NAD+ with vitamin C, B vitamins, magnesium or glutathione. Where significant nutritional deficiencies are identified, those issues should be addressed directly rather than assuming NAD+ is the answer to everything.

NAD IV Therapy for Weight Loss & Metabolic Health

NAD+ isn't a magic weight-loss molecule—and we'd rather tell you that than sell you a magic bag of vitamins. Its role in cellular energy metabolism, however, makes NAD IV Therapy an interesting adjunct to a broader metabolic-health program. Explore our approach to  weight loss and metabolic health, where thyroid function, hormones, nutrition, sleep and energy are all part of the conversation. NAD IV Therapy may be considered for patients interested in cellular-energy and wellness support, alongside appropriate nutrition, exercise and metabolic strategies. For an individualized NAD IV Edmonton protocol, our Naturopathic Doctors can determine whether NAD+ actually makes sense for your goals.

NAD IV Therapy for Thyroid Concerns

Thyroid dysfunction can leave people feeling tired, foggy and metabolically sluggish, and simply taking an energy supplement doesn't address the underlying issue. NAD+ is involved in cellular energy production, making it an interesting supportive therapy for patients whose thyroid concerns are also accompanied by persistent fatigue. Learn more about our naturopathic approach to  thyroid health and how we investigate thyroid, nutritional and metabolic factors rather than simply chasing symptoms. NAD IV Therapy can sometimes be incorporated alongside vitamin IVs and other supportive therapies, but it does not replace appropriate thyroid hormone treatment when that is medically indicated.

NAD IV Therapy for Skin Health

Healthy skin is about more than what you put on it. Cellular energy, oxidative stress, nutrition and the aging process all influence how skin looks and functions. Learn more about our approach to skin health and how NAD+, glutathione and IV vitamins can be incorporated into an inside-out wellness strategy. NAD+ is increasingly discussed in the longevity field because NAD-related pathways are involved in cellular metabolism and aging biology. Glutathione provides antioxidant support, while vitamin C and other nutrients may be incorporated into customized IV protocols. NAD IV Therapy is not a replacement for dermatological care, but it can be an interesting addition to a broader healthy-aging and skin-health strategy.

NAD IV Therapy for Mood & Brain Fog

When your brain feels like it is operating through molasses, “just try harder” isn't particularly helpful advice. NAD+ plays an important role in cellular energy metabolism, making NAD IV Therapy of interest to people experiencing fatigue, reduced mental energy and brain fog. Learn more about our approach to mood and brain fog and how nutritional, hormonal, thyroid and lifestyle factors can all contribute to cognitive symptoms. At TruMed, NAD+ may be combined with B vitamins, magnesium and other IV nutrients when appropriate. NAD IV Therapy is supportive rather than a replacement for appropriate medical or psychiatric treatment, but it may form part of a broader strategy for energy and wellness.

NAD IV Therapy for Autoimmune Conditions

Autoimmune conditions can be exhausting, both because of the disease itself and because chronic inflammation can place significant demands on the body. NAD+ is involved in cellular metabolism and has attracted scientific interest in inflammatory and aging pathways, although clinical evidence for using NAD IV Therapy specifically to treat autoimmune disease remains limited. Explore our naturopathic approach to  autoimmune conditions and how IV Therapy can be used as supportive care rather than as a replacement for conventional treatment. Depending on the patient, NAD+ may be combined with glutathione, vitamin C, B vitamins and other nutrients. The focus is on supporting overall wellness while the underlying autoimmune condition continues to receive appropriate medical management.

NAD IV Therapy for Fertility

Fertility is ultimately about healthy biology at the cellular level, which is one reason NAD+ has generated interest in the reproductive and longevity fields. That doesn't mean NAD IV Therapy is a fertility treatment—but it may be considered as part of a broader preconception wellness strategy. Learn more about our  fertility approach and how hormones, thyroid function, nutrition, iron status and overall health are assessed before adding supportive therapies. NAD+ may be combined with selected vitamin IVs or antioxidant nutrients such as glutathione when clinically appropriate. Fertility care is highly individualized, and NAD IV Therapy should be viewed as supportive wellness rather than a guaranteed fertility intervention.

NAD IV Therapy for Brain Injury & Concussion

Brain injury and concussion can leave people dealing with fatigue, brain fog, reduced concentration and poor exercise tolerance long after the initial injury. NAD+ is involved in cellular energy metabolism, making it an area of interest in research surrounding neurological health and cellular recovery. Learn more about our approach to concussion and brain injury and where NAD IV Therapy may fit within a broader recovery strategy. NAD+ may be combined with B vitamins, magnesium, vitamin C or glutathione depending on the patient's needs. While NAD IV Therapy is not a proven treatment for concussion itself, supporting nutrition and overall cellular health may be considered alongside appropriate neurological and rehabilitation care.

NAD IV Therapy for Cancer Support

Cancer patients and survivors sometimes seek IV therapies aimed at energy, recovery and overall wellness, but this is an area where careful coordination matters. Learn more about our supportive cancer-care approach and how IV Therapy can be considered alongside—not instead of—your oncology treatment. NAD+ plays fundamental roles in cellular metabolism, but that biology is complex in cancer, and NAD IV Therapy should not be promoted as a cancer treatment. Depending on the clinical situation, other IV nutrients such as vitamin C or glutathione may also be considered. Any NAD IV treatment for a patient undergoing cancer treatment should be individualized and coordinated appropriately with the patient's oncology team.

NAD IV Therapy for Multiple Sclerosis

MS-related fatigue can be stubborn, and patients understandably want more options for maintaining energy and function. NAD+ is involved in cellular energy metabolism and neurological processes, making it an interesting area of ongoing scientific research. Learn more about our naturopathic approach to Multiple Sclerosis and how NAD IV Therapy may be incorporated as supportive care for energy and overall wellness. NAD+ does not cure MS or replace disease-modifying therapy, but it may be considered alongside appropriate nutritional assessment and other supportive interventions. At our Edmonton Naturopathic clinic, IV protocols may also incorporate vitamins, magnesium or glutathione depending on the patient's individual needs.

NAD IV Therapy for Pediatrics

Children are not simply miniature adults, and NAD IV Therapy is therefore approached much more conservatively in pediatric patients. Learn more about our pediatric approach and how our Edmonton Naturopathic Doctors determine when intravenous nutritional support is actually appropriate. NAD+ is not a routine pediatric IV treatment and should only be considered in specific clinical circumstances after careful assessment. When pediatric IV Therapy is appropriate, treatment is generally focused on clearly identified nutritional or hydration needs rather than using adult-style longevity protocols. In other words, your eight-year-old probably doesn't need the same “anti-aging” IV as you do.

NAD IV Therapy for Long COVID

For some people, COVID ended months ago—but the fatigue apparently didn't get the memo. Persistent fatigue, brain fog, reduced exercise tolerance and poor recovery are among the reasons people with Long COVID explore supportive therapies such as NAD IV Therapy. Learn more about our naturopathic approach to Long COVID and how we investigate nutritional, metabolic and other potentially modifiable contributors to persistent symptoms. NAD+ is involved in cellular energy metabolism and may be considered as part of an individualized IV protocol, sometimes alongside vitamin C, B vitamins, magnesium or glutathione. NAD IV Therapy is supportive rather than a proven cure for Long COVID, and treatment should be tailored to the individual's symptoms and medical history.

NAD IV Therapy & Hyperbaric Oxygen Chambers

NAD IV Therapy and hyperbaric oxygen therapy are two very different treatments, but they share an interesting connection: both are frequently discussed in the context of cellular energy, recovery and healthy aging. Hyperbaric chambers expose the body to increased atmospheric pressure while breathing concentrated oxygen, increasing oxygen availability to tissues. Learn more about our Hyperbaric Oxygen Therapy in Edmonton and how HBOT can complement IV Therapy in selected recovery, performance and longevity programs. At TruMed, patients may choose IV nutrients such as NAD+, glutathione and vitamins alongside hyperbaric oxygen sessions when clinically appropriate. The two therapies should not be viewed as interchangeable—they work through different physiological mechanisms—but together they can form part of a broader wellness and recovery strategy.

NAD IV Therapy, TRT & Longevity

NAD IV Therapy and testosterone replacement therapy (TRT) occupy different corners of the longevity conversation, but they can be complementary when used appropriately. Testosterone influences muscle mass, bone health, libido, energy and body composition, while NAD+ is involved in cellular energy metabolism and pathways associated with aging biology. Learn more about our hormone and TRT services and how hormone optimization can fit into a broader healthy-aging and longevity strategy. For an appropriate patient, TRT may address clinically significant testosterone deficiency, while NAD IV Therapy may be considered as a separate supportive wellness intervention. Neither should be thought of as a fountain of youth in a bag—or a syringe—but both can have a place in a thoughtful, individualized longevity program when there is a sound clinical rationale

About Our Naturopaths

Our Naturopaths have undergraduate training and then have completed a four year doctorate in Naturopathic Medicine.

Our Naturopaths work with many natural treatments, and focus on functional medicine, infusions, injections, IV Therapy & Hyperbaric Oxygen.

Our Naturopathic Doctors use IV Therapy for Fatigue, Low Mood, Headaches, Skin brightening, hydration, Neurological disease, longevity and more!

Our infusion clinic is located in West Central Edmonton. 

IV Therapy in Edmonton – Nutrients That Work Overtime

At TruMed, we’re known for IV therapy that actually works. Why? Because we custom-tailor every drip. Instead of guessing, we give your body exactly what it needs—delivered directly into your bloodstream for 100% absorption.

Every treatment is customized to the patient’s needs, based on careful clinical assessment and, when indicated, laboratory evaluation. With a focus on science, safety, and individualized care, TruMed has become Edmonton’s most trusted destination for  IV therapy and advanced infusion medicine.

Whether it’s beating burnout, fighting infections, or boosting long-term wellness, IV therapy gives your cells the fuel they need to perform. Our most popular IVs include:

• Myers’ Cocktail – the ultimate energy & immunity booster

• High-Dose Vitamin C – immune support + collagen repair

• Glutathione IVs – detox & skin-brightening powerhouse

• NAD+ IVs – mitochondrial support & anti-aging therapy

With over 15,000 IV treatments delivered in Edmonton, TruMed is the city’s go-to for safe, effective nutrient therapy.

Edmonton’s  Leading Clinic for IV Therapy & Advanced Infusion Medicine

At TruMed Naturopathic Clinic, we are committed to providing advanced, evidence-informed therapies that restore health and vitality. Our combination of IV vitamin drips, NAD+ infusions, Glutathione therapy, IV iron treatments, and hyperbaric chamber sessions allows us to address a broad spectrum of patient concerns with precision and safety.

Iron Infusions

A synergist with NAD injections, Iron infusions at TruMed typically take about 60 minutes, followed by a short observation period. Most patients require only one or two infusions to restore iron and ferritin levels, depending on lab results and individual needs. All treatments are prescribed and supervised by our Nurse Practitioner, ensuring personalized care and close monitoring.

Who Benefits from Iron Infusions?

We often recommend IV iron for patients with:

• Iron-deficiency anemia or chronically low ferritin

• Fatigue, weakness, or shortness of breath related to low iron

By restoring healthy iron levels quickly and efficiently, TruMed helps patients get back to living with energy, strength, and resilience.

Glutathione IV Therapy in Edmonton

Often paired with NAD, IV Glutathione is the body’s master antioxidant, regulating detoxification, oxidative stress, and skin health.

Glutathione drips are often short, administered over 5–15 minutes, and can be paired with vitamin cocktails for enhanced efficacy.

At TruMed, we have administered thousands of Glutathione drips and injections in Edmonton since 2010..